WebThe gene expression signature for hyperlipidemia was estimated using the whole blood elastic net model (tissue = “TW_Whole_Blood_Elastic_Net_0.5”) [2] and GWAS summary statistics from the Global Lipids Genetics Consortium with 188,577 individuals (phenotype = “GLGC_Mc_LDL”). [3,4] The file was downloaded from “ … Web15 Jul 2024 · Using a global lipidomic analysis, another landmark study identified 12,13-dihydroxy-9Z-octadecenoic acid ... For the fasting lipid traits, we used the findings of the Global Lipids Genetics Consortium (GLGC; based on N of up to 94,595) . As outcome data, we used summary statistics of genome wide association study ...
Plasma lipids and risk of aortic valve stenosis: a Mendelian ...
Web5 Jun 2024 · We apply MTAR to rare-variant summary statistics for three lipid traits in the Global Lipids Genetics Consortium. 99 genome-wide significant genes were identified in … Web29 Mar 2024 · Shown are the multivariable MR (MVMR) results from the discovery analysis, using genetic instruments for plasma TG levels from Global Lipids Genetics Consortium (GLGC) and disease traits from UKB. Levels of statistical significance are categorized into three tiers: Tier 1 (BB): At least Bonferroni-significant in both the discovery (p<1.92 × 10 … huaraches negros
GLGC - lipidgenetics.org
Web11 Sep 2024 · This study aimed to assess a potential causal relationship between genetic variants associated with plasma lipid traits (high-density lipoprotein, HDL; low-density lipoprotein, LDL; triglycerides, TGs) with risk for BC using Mendelian randomization (MR). Methods and findings Web27 Sep 2024 · Study overview. BCAC: Breast Cancer Association Consortium, Egger MR Egger method, EUR European reference sample, GLGC Global Lipids Genetics Consortium, HDL-C high-density lipoprotein-cholesterol ... hofmann leasing uslar